General Information

  • ID:  hor002479
  • Uniprot ID:  NA
  • Protein name:  NGFFFamide
  • Gene name:  NA
  • Organism:  Strongylocentrotus purpuratus
  • Family:  NA
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  NGFFF
  • Length:  5
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T5 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Cause contraction of tube foot and oesophagus preparations
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor002479_AF2.pdbhor002479_ESM.pdb

Physical Information

Mass: 70222 Formula: C33H38N6O7
Absent amino acids: ACDEHIKLMPQRSTVWY Common amino acids: F
pI: 6.11 Basic residues: 0
Polar residues: 2 Hydrophobic residues: 3
Hydrophobicity: 90 Boman Index: 324
Half-Life: 1.4 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 0
Instability Index: -2206 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  19329739
  • Title:  NGFFFamide and Echinotocin: Structurally Unrelated Myoactive Neuropeptides Derived From Neurophysin-Containing Precursors in Sea Urchins